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In uncomplexed structures of human (monE, monC, PDB code 2j3n) 16 and rat TrxR1 (PDB code 3eao and 3ean) 15 , this distance decreases to about 13 , implying that the flexible C-terminal arm adopts different conformations upon catalysis (Figs 3 and 4)
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They had a reconstitution problem
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