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These comorbidities have an influential effect on outcomes, possibly leading to HFpEF-associated mortality ranging from 15% at one year to 75% at five to ten years after hospitalization.(2) Unlike HFrEF, HFpEF lacks proven survival benefits from guideline directed medical therapy (GDMT)
Dose-dependent gastric emptying delays are most pronounced
Slowing the ramp to the label cadence (2.5 mg start, 2.5 mg steps, four-week holds) dropped that to mid-single digits at every maintenance dose, at no cost to the 12-week result, and the dedicated slow-titration trial reached placebo range. Reaching 15 mg is not the problem
Recent years have added a different kind of human data: qualitative sociology
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High-fat or heavy meals are more likely to trigger symptoms
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