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This dose of L2-Cmu was based in part on a prior pharmacodynamic (PD) study in which L2-C achieved similar suppression of tumor growth in vivo as Ganitumab 25

Self-delivery of evolved proteases into cancer cells To harness the self-delivery capabilities of BoNT proteases, we expressed and purified evolved proteases X(PC) and X(GD) as fusions with the wild-type BoNT/X translocation domain (H N )

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