For example, a 5 mg vial reconstituted with 2 mL of bacteriostatic water gives 2.5 mg/mL
Stock solutions of 110 mg/mL are typical and are then diluted into culture medium for working concentrations
What the animal studies cannot tell us includes optimal human dosing, population-specific responses (elderly, children, pregnancy), long-term safety in humans, rare side effects that require large sample sizes to detect, and interactions with medications or medical conditions
The main risks stem from both peptide activity and contamination from low-quality suppliers
However, discontinuation rates are similar for both treatments (approximately 6%), suggesting that while CagriSema causes more frequent gastrointestinal symptoms, they are generally manageable