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GLP-1s account for 23% of first line diabetes therapy in 2025 up from 3% in 2021 Since 2019, the American Diabetes Association (ADA) has revised its Standards of Care each year to expand the role of GLP-1 receptor agonists and SGLT2 inhibitors as first-line treatments for T2D 2

[1] [7] Referral triggers include severe or persistent gastrointestinal symptoms, signs of pancreatitis, symptoms suggesting gallbladder disease, unexplained worsening of autoimmune disease activity, or any concerns about medication interactions with immunosuppressive therapy

Dartmouth Health

These symptoms require prompt medical attention and testing