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Strong target identification normally requires orthogonal evidence such as direct binding, receptor-specific functional assays, selective antagonism, genetic loss of function, rescue experiments, and biophysical or chemical target-engagement analysis

Anything above 35 degrees Celsius begins compromising the peptide structure

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In addition to curcumin derivatives, metal complexes with other 1,7-diaryl-1,6-heptadiene-3,5-diones or 1,7-diarylheptanoids were also obtained

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