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We all have the same reward systems that are absolutely essential to normal functioning, Pontzer says, and its only when we get toward the real far end of the spectrum on those reward responses that we get into trouble. This hormonal system is evolutionarily ancient

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[27] The connection between GSTP inhibition of the pro-apoptotic JNK pathway and the isozyme's overexpression in drug-resistant tumor cells may itself account for the tumor cells' ability to escape apoptosis mediated by drugs that are not substrates of GSTP