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The field is moving quickly, and newer medications in clinical trials are producing greater weight lossbut with important tradeoffs

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doi: 10.1053/j.gastro.2012.06.031 157 GhaniRMullishBHRobertsLADaviesFJMarchesiJR

Maintaining proper concentrations of glycation products depends on a balance between, on the one hand, their endogenous formation and dietary intake, and on the other hand, the activity of antiglycation system and digestion of glycotoxins in the gastrointestinal tract

It was later approved in November 2023 as Zepbound for obesity treatment