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J Pharmacol Exp Ther 268: 978984

PMID: 110 CamargoLDNRighettiRFde AlmeidaFMDos SantosTMFukuzakiSMartinsNABet al

The results are mean values of at least 4 different experiments (50100 cells per experiment)

This is because the longer food and acid remain in the stomach, the greater the chance for them to move back up into the esophagus, especially when the lower esophageal sphincter is weakened or relaxes inappropriately

However, many people experience dramatic improvement or near-complete resolution of symptoms by addressing root causes: healing gut inflammation to restore DAO production 24 , supporting methylation for HNMT function, stabilizing mast cells, and identifying personal triggers