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Published cosmetic studies on GHK-Cu skin effects used daily application over 8-12 week periods before assessing results

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1 2 3 Siuzdak G, Stanley CA (May 2002)

2.13.1.2 E693del (Osaka) mutation The APP E693-Tg (Osaka) mouse model, which carries the Osaka mutation (APP695) under the control of the mouse prion promoter, expressed comparable levels of mutant human APP and endogenous mouse APP