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Starting at the lower end (2 g at bedtime) gives you a clear signal of tolerability before escalating

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The landmark STEP trial compared semaglutide plus lifestyle changes to lifestyle changes alone

These shifts may impact the menstrual cycle or trigger breakthrough bleeding, especially in premenopausal women or those with underlying hormonal imbalances

A full one-third of the insurers higher spending was driven by high pharmaceutical outlays, and much of that was the cost and high volume of prescriptions for the blockbuster GLP-1 medications, which have long been used to treat diabetes but have become wildly popular to treat obesity