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11.6 Diversification of probiotic sources and delivery vehicles Regarding delivery matrices, the future sources of probiotics are expected to diversify beyond traditional fermented dairy, cereals, fruits, and vegetables to encompass novel vehicles such as meat, fish, honey, and even environmental origins like soil (536)
While endogenous carriers like extracellular vesicles or biomimetic coatings are designed to minimize immune recognition, the introduction of targeting ligands, synthetic polymers, or residual manufacturing components can provoke unintended inflammatory or foreign body responses, potentially neutralizing the therapeutic effect or causing adverse events
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Blood 62(Suppl 1):204a, 1983
Epitalon attenuated this effect, especially when the treatment was continued throughout the experiment (group 2)
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