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Cancer involves sustained, uncontrolled VEGF production
In brief, activation of the GCN2-ATF4 amino acid stress pathway and inhibition of protein synthesis through inhibition of mTORC1 demonstrates the strong proteogenic role played by cysteine in tumor cells
2015: Pickart et al
Georgakis GV, Li Y, Humphreys R, Johnson R, Andreeff M , Fiscella M, Pukac L, OBrien S, Albert V, Younes A
Shim T, Strum DP, Mudry A, Monfared A
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