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The key findings relevant to this question: No clinically relevant drug-metabolizing enzyme-mediated interactions have been reported for GLP-1 agonists Some transporters (OATP1B1/3, OAT3) showed inhibition with GLP-1 agonist treatment in vitro Significant changes in oral contraceptive and levothyroxine absorption were documented with tirzepatide and oral semaglutide GLP-1 agonists delay gastric emptying, which can alter absorption of co-administered oral medications Critically, no published study has examined the drug-drug interaction profile of two injectable GLP-1 agonists administered concurrently

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The E MAX value indicates the maximum BRET signal expressed as fold change from baseline

GLP-1R agonists effects on cardiovascular events The first pieces of evidence of the potential clinical benefit of GLP-1 agonists have emerged recently, pointing to a decrease of major adverse cardiovascular and cerebrovascular events (MACCE) including stroke, MI, cardiac mortality, acute coronary syndrome, and revascularization procedures