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Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice
Based on available evidence, SCFAs exert protective effects by activating the Nrf2/GPX4 pathway to inhibit lipid peroxidation, while LPS acts through the dual mechanisms of suppressing the antioxidant defense system (GPX4) and disrupting iron metabolic homeostasis
Upon activation of cell death induced by hepatic stimuli, IL-1 family cytokines released by dying liver cells stimulate the recruitment of immune cells, which in turn affect inflammation and subsequent liver damage
High doses of glutathione, particularly through injections, may lead to reduced melanin levels, which can result in white or grey hair as a side effect of skin whitening treatments
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