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Side Effects of Qsymia for Weight Loss The most common side effects, reported by 5% or more of patients, include: Paresthesia (tingling in hands, feet, or face), reported by about 20% of patients Dry mouth Insomnia , especially if taken later in the day Dizziness Constipation Taste changes , particularly with carbonated drinks Mood changes , including irritability or low mood Difficulty concentrating or brain fog with higher doses of topiramate Less common but more serious risks include: Increased heart rate Acute glaucoma (rare, but requires immediate discontinuation) Kidney stones Birth defects (Qsymia is in a Risk Evaluation and Mitigation Strategy or REMS program, due to teratogenicity risk) Qsymia should not be used during pregnancy, in patients with glaucoma, hyperthyroidism or those taking MAOIs

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