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High temperatures cause oxidation, which lowers its benefits for detox and immune support

Conservative protocols starting at 0.25 mg daily suit first-time users and those with minor injuries

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GHK-CU modulates gene expression and copper metabolism

Other factors: While there are many other factors which can create a paradoxical reaction (fear of the IV, fear of treatment / getting well, mental emotional resistance to therapy such as seen in anorexia nervosa etc.) these are situational and less common than the above listed reasons