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Firstly, activated NF-B and NLRP3 inflammasome in DN promotes inflammation and increases fibronectin and collagen deposition in kidney, 41,42 leading to thickening glomerular basement membrane, glomerular sclerosis, podocyte damage, and ultimately kidney fibrosis

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Third, stay well-hydrated to support kidney function, especially since both NSAIDs and semaglutide can put extra stress on the kidneys

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