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Directly and indirectly through multiple reactions which include enzymatic reactions, glutathione is oxidized to form GSSG, which is then reduced to GSH, its "active form" by yet another enzymatic reaction (3)
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ZDHHC7 and APT2 promote the formation and nuclear translocation of the SMAD2-STAT3-SMAD4 complex by regulating the palmitoylation-depalmitoylation dynamic balance of SMAD2 and STAT3, thereby driving the differentiation of naive T cells into Th17 cells
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