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10.1089/ars.2006.8.1865 Antioxid Redox Signal
CJC-1295 and Somatotroph Biology The GHRH-receptor signalling pathway activated by CJC-1295 stimulates adenylate cyclase, increasing intracellular cAMP and engaging PKA-linked transcriptional regulation of the GH gene in somatotroph cells with in vivo research confirming increased pituitary RNA, GH mRNA, and somatotroph cell number following administration, establishing that GHRH-class secretagogues act on multiple levels of GH axis biology beyond simple acute secretion
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(2015) tested intra-articular AOD-9604 in a collagenase-induced rabbit osteoarthritis model
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