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A brief room-temperature equilibration period before opening a freezer-stored vial is normal, but reconstituted solutions should be returned to refrigeration promptly after each use

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But waiting might not he the best strategy while interest in the drugs explodes

The steps, described in detail below, are (1) cohort identification, (2) effectiveness estimation for clinical outcomes of interest, (3) cost estimation, (4) base-case analysis, and (5) sensitivity analyses

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