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For surface modification advancement, biomimetic membrane coating (e.g., with renal tubular epithelial cell or macrophage membranes) outperforms conventional ligand-based targeting (e.g., folate, peptides) by inheriting native cell receptors, improving biocompatibility, and enabling inflammation-guided chemotaxisaddressing the clinical challenge of nonspecific drug distribution in RIRI patients with heterogeneous lesion locations

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