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Some providers also use metformin or glyburide during pregnancy, though these are less preferred than insulin
The Phase 3 SYNERGY trial (NCT06859268) will evaluate whether retatrutide can resolve steatohepatitis (liver inflammation) and fibrosis, endpoints that would be required for regulatory approval specifically for liver disease treatment
An additional study called ATTAIN-MAINTAIN found that orforglipron helped people hold onto weight they had previously lost with injectable GLP-1 therapies, opening up a potential step-down strategy for people who want to transition from weekly injections to a simpler daily pill once they have reached their target weight
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While a bit rare, Semaglutide has shown some more severe side effects during testing, including: Allergic reactions (including swelling of the face, tongue, or throat
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