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The goal is to offer the same benefits as current GLP-1 medications, like semaglutide or tirzepatide, without the need for injections
Se clasifican en clase A si la puntuacin es de 5-6 puntos, clase B si es de 7-9 puntos y clase C si es de 10-15 puntos, donde la clase A tiene la mayor supervivencia al cabo de un ao (100%) y 2 aos (85%) y la case C tiene la peor supervivencia al ao (45%) y a los 2 aos (35%)32
Regarding glucose-metabolism, two studies found that GLP-1(9-36), GLP-1 (7-36) and Liraglutide significantly inhibited insulin-stimulated glucose uptake [12, 13], with Liraglutide showing a dose dependent inhibition, with a maximum at a concentration of 1000 nM [12, 13]
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Patients are randomized to 2.5 to 5 years of weekly semaglutide injections or placebo as an adjunct to standard care
