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The samples were injected into an Agilent Eclipse Plus reversed-phase C18 column (2.1 mm 150 mm, 1.8 m particle size, 95 pore size) for separation
Anaphylaxis is a severe and life-threatening allergic reaction
MT1 as afamelanotide is delivered as a subcutaneous implant (16 mg per implant, replaced every 60 days in clinical use), which is a fundamentally different pharmacokinetic profile than the repeated subcutaneous injections used in MT2 self-administration
Generally, no data were excluded
J Clin Endocrinol Metab2008 Oct;93(10):3703-16
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