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People with pre-existing digestive disorders, a history of gastric surgery, or those already experiencing mild digestive symptoms should discuss these concerns with their healthcare provider before starting treatment

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The tirzepatide doses of 10 and/or 15 mg demonstrated superiority compared to placebo for the coprimary endpoints percentage body weight reductions from baseline at week 72 and the proportion of patients achieving 5% body weight reduction at week 72

Mediators Inflamm (2016) 2016:3094642