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4c, we show that treatment with ENDO3 decreased endolysosomal activity, which recapitulated what was observed in Munc13-4-deficient cells 16 , further validating that the ENDO compounds inhibit Munc13-4-mediated endosomal maturation
GLP-1 agonists have also shown strong efficacy in clinical trials, with patients achieving an average weight loss of 15-25%, further promoting rapid adoption
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