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Most treatment discontinuations were due to gastrointestinal AE and occurred during the rapid escalation phase this may be mitigated with more gradual dose escalation at phase 3 trials
April 2003, 18(2):61-71
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This includes reviewing medical history, current medications, and potential drug interactions
But for a pharmaceutical that might spend $500 million a year, its a small percentage to take a pretty strong risk on, said one holding company media buyer, who asked to speak anonymously due to the sensitivities of their agencys pharmaceutical clients
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