The BDNF Isoforms Positively and Negatively Contribute to Maintenance of Brain Homeostasis One of the most important features of BDNF synthesis is the elaboration of several functionally active isoforms, such as pro-BDNF, m-BDNF, pro-domain sequence, and Val66Met polymorphic pro-domain variant
*Correspondence: Tiziana Crepaldi, [email protected] This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
Oral formulations may require longer durations given the bioavailability uncertainty
High-dose oral therapy (10002000 micrograms daily) can be effective even in pernicious anaemia, as approximately 1% of B12 is absorbed through passive diffusion independent of intrinsic factor
Diagnosis of an underlying absorption disorder, significant anaemia or neurological disease may require GP or specialist investigation
