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Therefore, further clinical studies are needed to verify whether therapies GLP-1 functional agonists could be used as supportive therapy to currently available antidepressant drugs or whether these compounds would have a beneficial effect in patients suffering from treatment-resistant depression [120]
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It has been reported that there is no reduction in its secretion in patients with T2DM [13] but a nearly total loss of insulinotropic effect is observed, even at supraphysiological concentrations, implying the existence of GIP resistance [14]
13 As our understanding of their mechanisms continues to evolve, these agents offer promising new avenues for improving outcomes in HF patients.
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