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Efficacy and safety of N-acetylcysteine as add-on therapy in the treatment of obsessive-compulsive disorder: A systematic review and meta-analysis
However, CYP2E1-driven metabolism generates substantially more reactive oxygen species per unit of ethanol oxidized than the ADH pathway
Some limitations should be acknowledged here
That evidence would need to come from randomized controlled clinical trials that directly compare the use of the drugs against a placebo, or dummy medication
The crystal structure of the wild-type AR illustrated the reason why the LxxLL motifs of typical NR coactivators fail to hydrogen bond with Glu897 of H12 and make fewer and less optimized hydrophobic contacts with the AF2 pocket compared with FxxLF-containing peptides, explaining the lower affinity of AF2 for the LXXLL-containing p160-type coactivators 82
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