Patients with T2D obtain substantial benefits with even moderate weight loss
Exenatide administered once weekly as opposed to twice daily was found to lower HbA1c more significantly in the DURATION- 1 and DURATION- 5 trials ( 1.9% vs
National Library of Medicine , "FDA Approves Ozempic (Semaglutide) as the Only GLP-1 RA to Reduce the Risk of Worsening Kidney Disease and Cardiovascular Death in Adults with Type 2 Diabetes and Chronic Kidney Disease." PR Newswire , "FDA Approves Wegovy (Semaglutide) for Adults with Obesity." Drugs.com , 2021, Fonseca, Vivian A., et al
Additionally, GLP-1 receptor agonists not only play an essential role in glucose metabolism and energy conversion but also exhibit significant anti-inflammatory and antioxidative stress effects
Crosby L, Davis B, Joshi S, Jardine M, Paul J, Neola M, et al