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It is a complex network of interlocking genetic feedback loops involving clock genes (Clock, Bmal1), period genes (Per1, Per2, Per3), and cryptochrome genes (Cry1, Cry2)
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Blood was collected via jugular vein catheters, centrifuged to obtain serum, and stored at -20C
The stability window interacts directly with the dosing schedule, and this is a practical planning point rather than a theoretical one: at 2.4 mg/week a 10 mg vial covers four weeks, which lands exactly at the outer edge of the in-use window
10.1016/j.stemcr.2019.01.009 52 FurihataT.KawamatsuS.ItoR.SaitoK.SuzukiS.KishidaS.et al
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