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In the UK, NICE recommends GLP-1 receptor agonists for type 2 diabetes under specific circumstances, typically when metformin and other treatments have not achieved glycaemic targets, or in people with specific cardiovascular risk factors

A third randomized trial compared high-dose (10 mg/day) and low-dose (1.28 mg/day) vitamin B 6 in 60 pregnant women experiencing nausea and/or vomiting prior to the twelfth week of gestation (77)

What About Long-Term Use and Stopping the Medication

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semaglutide is unambiguously a GLP-1-only mono-agonist