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tobacco use within 3 months of enrollment
(20) Activating this pathway helps promote the burning of fat, rather than glucose, for fuel, similar to what happens when you fast or follow a ketogenic diet
This distinction matters enormously when we talk about combining it with tirzepatide
Research points to hormonal imbalances, appetite regulation, and genetic factors as major reasons why diets alone rarely produce lasting results
However, tirzepatide is a notable exception because it can reduce the absorption of oral hormonal contraceptives by slowing stomach emptying more strongly
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