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30 Similar to other salicylate products, bismuth subsalicylate should not be used in the second and third trimesters due to risks to the mother and fetus

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In a phase 3 randomised trial, a deoxycholic-acid injectable significantly reduced fat under the chin compared with placebo, and a three-year follow-up found the improvement was durable with a reassuring long-term safety profile

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however, they should be reserved for inadequate weight loss despite implementing lifestyle interventions, according to the American Association of Clinical Endocrinologists (AACE) and American College of Endocrinology (ACE) 2016 clinical practice guideline