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Examples of drugs that exhibit flow dependent hepatic clearance (high hepatic extraction ratio) include: Morphine , Lidocaine, Verapamil, Nitroglycerin, Propranalol Flow-Dependent Clearance The clearance of high-extraction drugs is primarily dependent on hepatic blood flow

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Tryptophan is one of the essential amino acids in the human body and is decomposed mainly through the kynurenine pathway, in addition to producing physiologically active substances, such as 5-hydroxytryptamine and melatonin

Data are plotted as means SD (n = 3 biologically independent samples)