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Oxidative Med Cell Longev 2017:3724545

Whereas the TMPRSS2-PAR2 pathway is a predominant homeostatic driver of GIP in physiological conditions, in obesity TMPRSS2 deletion fails to reduce GIP and, presumably, GIP-dependent weight gain

Anti-inflammatory effects: Rather than broadly suppressing inflammation, BPC-157 appears to modulate inflammatory responses toward healing rather than chronic inflammation

Since then, several clinical studies have shown its safe and effective use - but the pharmacuetical companies have decided not to (yet) pursue FDA-Approval (likely because each new FDA-Approval costs several million dollars to go through the process, and because there are a good deal of drugs used off-label in the way tranexamic acid is for melasma, especially when the drug has a long history of safety and efficacy, as is in this case)

Swissmedic has flagged Lemon Bottle for mislabeled ingredients , highlighting potential regulatory issues