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[11] Therefore, caution should be taken when initiating, changing or discontinuing thyroid agents

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Studies in model organisms and humans have demonstrated that this group of genes is dosage-sensitive, with haploinsufficiency serving as the primary disease mechanism (Fahrner and Bjornsson, 2019)

So, this aligns with experiences out there

Mechanisms of action: NF-B inhibition: KPV inhibits the activation of nuclear factor kappa-B (NF-B), the master regulator of the inflammatory response