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Notably, GLP-1 significantly suppressed plasma pancreatic polypeptide concentrations following the first meal, 68 but this effect diminished substantially after the second test meal, 72 suggesting autonomic nervous system adaptation to continuous GLP-1 administration
PMCID: PMC8615599
Their HbA1c levels, a measure of long-term blood sugar control, improved less than those of non-carriers
Instead, it changes how your body handles hunger and fullness, which makes it easier to naturally eat less without feeling deprived
And I use that analogy when I'm working with patients to really reinforce that it is a chronic relapsing sometimes I don't use disease, people again don't like disease, I'll say condition we can treat it but we don't know exactly how to maintain that healthier body weight without the medication long term in most people
