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Insufficient human clinical trials have led to a lack of data to determine a safe dose
The main one
Descriptive epidemiology of Parkinson's disease: Distribution and hypothesis formulation
To investigate glucose levels and GLUD1 regulation, we established glucose concentration gradients and observed that high glucose destabilized GLUD1 by inhibiting the PI3K/AKT pathway, whereas glucose downregulation, achieved by insulin or metformin treatment, promoted GLUD1 protein accumulation
"Evidence-based guideline update: treatment of essential tremor: report of the Quality Standards subcommittee of the American Academy of Neurology"
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