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Materials and Methods Animals Forty-four age-matched (two-month-old) Sprague Dawley rats were bred at the University of British Columbia and used in this study ( n = 22 per sex)

Lean muscle mass remained stable or increased slightly in 78% of participants, indicating the fat loss was not accompanied by muscle wasting commonly seen with caloric restriction alone

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These may include excessive thirst, skin conditions, blurry vision, abdominal cramps, nausea, vomiting, and increased risk of severe side effects for individuals with existing health conditions