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Gualtierotti, R
In animal models and in the clinical setting, distinct pharmaceuticals have been described to modulate the function of transporters or enzymes involved in the metabolic dynamics of amino acids (Table 11)
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Protein expression in acute myelogenous leukemia stem cells compared to bulk AML cells using reverse phase proteins arrays (RPPA)
In addition, deletion of the GSH1 geneencoding glutamylcysteine synthetase (GCS), the enzyme catalysing the first step in glutathione synthesiswas shown to suppress an Ero1 conditional mutant, again indicating that GSH provides an additional load on Ero1 activity (Frand & Kaiser, 1998)
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