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Larger, well-designed randomized controlled trials are warranted to clarify efficacy, confirm findings in adequately powered addiction-focused studies, identify responsive subgroups, and establish appropriate treatment protocols
however, metformin is associated with failure in glycaemic control in approximately half of adolescents 13 , and insulin is associated with hypoglycaemia and weight gain 4,5
Separate zinc supplements from tetracycline or quinolone antibiotics by at least 2 hours, as zinc can reduce their absorption
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