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Real-world impact of adding a glucagon-like peptide-1 receptor agonist compared with basal insulin on metabolic targets in adults living with type 2 diabetes and chronic kidney disease already treated with a sodium-glucose co-transporter-2 inhibitor: the impact GLP-1 CKD study

In the SURMOUNT-1 trial, adults without diabetes on tirzepatide lost an average of 15-22% of body weight over 72 weeks, depending on dose

He is, in other words, no reflexive skeptic of these drugs, which is exactly what makes his account of their limits worth hearing

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Still, they can happen when the risks were not fully known or when a safer option existed and was not used