The overall well-being score was 0.06 standard deviations higher per genetically predicted 1 kg/m reduction in BMI
Some people split into twice-daily dosing under provider guidance, taking half the dose in the morning and half in the evening
Interestingly, despite increased expression of IGF-1, the relative rate of loss of muscle mass and strength is not attenuated in virus-injected versus control muscles
The Endocrine Society's guideline on obesity pharmacotherapy includes the recommendation that "clinicians should counsel patients that responses to anti-obesity medications vary, and that expectations should be guided by clinical trial data, not anecdotal reports" 7
The mean percentage change in weight at week 72 was 15.0% (95% confidence interval [CI], 15.9 to 14.2) with 5-mg weekly doses of tirzepatide, 19.5% (95% CI, 20.4 to 18.5) with 10-mg doses, and 20.9% (95% CI, 21.8 to 19.9) with 15-mg doses