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Yes, but its usually modest

Immunogenicity (rare allergic-type reactions) was named in FDA review documents for ipamorelin and CJC-1295

Bibcode:1992PNAS...89.8641T

So some doctors are prescribing it for addiction related purposes but theyre doing it off-label, so it means that the drug itself hasnt been approved for those purposes

Do not store in the door of the refrigerator where temperature fluctuates most