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Discussion The diagnosis of malignant peripheral nerve sheath tumor is difficult and has historically suffered from a lack of entirely specific histological criteria, ancillary immunohistochemical and molecular diagnostic markers, especially outside the NF1 context

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Efficacy also showed a modest reduction with age: each additional 10 years of age corresponded to a 0.5% reduction in BMI change (around 0.45 kg reduced weight loss efficacy), which is directionally consistent with recent clinical trial meta-analyses 12,13

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