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Oral bioavailability is expected to be negligible given the peptide's large size, and subcutaneous or intravenous delivery would likely be required for any human application

10.1016/j.etap.2016.01.021 20 LygoeK

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Similarly, PEGylated IL-1Ra chimeric protein nanoparticles prolong half-life, enabling sustained blockade of the IL-1 pathway and inhibition of MSU crystal-induced inflammation