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Start Free Assessment Table of contents Why the question comes up: the psychology behind wanting to split doses The pharmacokinetics that make weekly dosing work What the clinical trials actually tested What happens when patients split their weekly dose in half The side-effect assumption: does splitting reduce nausea
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Some patients may be candidates for switching from semaglutide to tirzepatide, but this decision should be made with a physician
Switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after starting medication and for 4 weeks after each dose escalation until you reach a maintenance dose
The rationale is that lower tirzepatide doses leave more room for complementary compounds without overwhelming the system
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